MS Stages: What to Expect: What to Bring?

Traveling from a foreign country can be an expensive venture, with traveling around the city even more so! So I thought it might be helpful for those who haven’t been before to know what type of stuff is needed/what you should bring as far as luggage goes.

You need a good suitcase that’s carry-on-sized because if they weigh your bag during check-in and it exceeds the weight allowance – which happens – you have to pay extra to have it checked in afterward! The fee usually isn’t cheap either, so be sure not only to buy a good suitcase but also keep checking online or on airlines’ websites for updated baggage weight allowances. I usually try and stick around 23 kgs just in case they change it.

As far as clothes go, you’ll want to pack warm and comfortable things because you may be there for a while, so jeans and tracksuit pants are the best things to bring along. Bring scarves and beanies too – even in summer – because they can make great accessories or substitutes for blankets at night if the weather is cold. And do not forget your sunglasses! They will become your best friend during those long days on-set where you’re waiting around hours upon hours.

Other than that, don’t feel like you have to overpack everything else. You can buy most things once you get there with ease; I’ve seen goods sold everywhere from 7/11s to street stalls near the studio complex.

Prices aren’t too bad, but they are a little more expensive than back here in Australia so be warned. Also, bring lots of snacks with you to the set! You are allowed to have food with you there, but I’d recommend keeping them in your car until lunchtime just in case. And lastly, try and keep it light because sometimes taking large suitcases onset can be a pain in the arse.

multiple sclerosis progression timeline:-Multiple Sclerosis (MS) is a disease in which the immune system attacks and damages myelin, the fatty white substance that surrounds and protects nerve fibers, and causes communication problems between your brain and the rest of your body.

Multiple sclerosis progression timeline Multiple sclerosis is a chronic inflammatory demyelinating disorder of the central nervous system (CNS). This results in patchy transverse myelitis with plaque formation, gliosis, neuronal loss, demyelination within plaques, and Wallerian degeneration.

[1] The primary pathological process leading to MS involves the autoimmune-mediated destruction of oligodendrocytes via a multifactorial process. Anti-myelin antibodies have been detected in patients with MS since the 1950s.

[2]  The presence of myelin basic protein (MBP) autoantibodies in the serum of MS patients was demonstrated by the 1960s.

[3] In 1975, a myelin-oligodendrocyte glycoprotein antibody was found to be present in the sera of approximately 70% of MS patients and only 3%-5% of healthy individuals.

[4] During that decade, a definite correlation between disease duration and concentration of this antibody in a patient’s serum was established; it is presently considered one of three major markers for diagnosing the condition (the other two being oligoclonal bands indicator of intrathecal IgG production and elevated immunoglobulin G indices).

[5] In the 1980s, myelin basic protein was not only recognized as a component of the CNS but as a self-antigen as well, and as such it became an obvious target for an autoimmune reaction.

How do I know if my ms is progressing:

The diagnosis of MS requires a history of two or more neurologic events with a minimum of 24 hours between the events and in the absence of infection or other identifiable causes. The most common initial manifestation is unilateral optic neuritis, which occurs in approximately 65% of newly diagnosed patients.

Multiple sclerosis progression timeline Other common presenting conditions include transverse myelitis, brainstem syndromes (such as internuclear ophthalmoplegia), cerebellar ataxia, dysarthria, gait abnormalities, weakness of an extremity, spasticity of an extremity, paresthesias involving an arm or leg on one side of the body, sensory disturbances involving loss of sensation over part or all areas of the body, and bladder dysfunction.

Symptoms are usually constant but may wax and wane for a few hours or days. Myasthenia gravis causes similar symptoms, whereas other neurological conditions that can mimic MS include Lyme disease, syphilis, sarcoidosis, carcinomatous meningitis, atypical polio, Guillain-Barre syndrome, tumors of the CNS or brainstem, systemic lupus erythematosus, Wegener’s granulomatosis, Behcet’s disease, Sjogren’s syndrome, vitamin B12 deficiency, adult-onset Tay-Sachs disease

multiple sclerosis progression timeline The magnetic resonance imaging (MRI) scan of the brain in MS typically shows one or more lesions in the white matter, which are hyperintense on T2-weighted images and corresponding to areas of demyelination.

These can appear as plaques (areas with a sharp border) or as diffuse atrophy involving multiple patches of white matter. The lesions may be small and discrete or very extensive, confluent with normal-appearing white matter. Typical sites include the corpus callosum, internal capsule, periventricular white matter, cerebellar hemispheres, brainstem, and spinal cord.

Multiple sclerosis cognitive problems:

There is evidence that myelin breakdown releases substances that trigger inflammation. This process induces a wide range of symptoms that vary in severity during different phases of the disease process.

Chronic progressive multiple sclerosis:

The more common phenotype is primary progressive MS (PPMS), defined as having steadily declining neurological findings, without relapses or remissions, walker gait, and severe fatigue. Secondary progressive MS (SPMS) is characterized by a gradual decline in function after an initial period of stability, superimposed on a background of relatively mild symptoms. SPMS typically affects women more severely than men.

As the name denotes, patients with this form have experienced at least one relapse of their symptoms (a clinically defined syndrome often lasting less than 24 hours) or remission that lasted for longer than six months; before any treatment was available it usually took 10-15 years to progress to SPMS.

This is the most common form in northern Europe, North America, and Australia; in contrast, chronic progressive or relapsing-progressive MS (RPMS) is prevalent in southern Europe, Asia, and Africa.

The disease begins with a relapse (often preceded by milder symptoms) that usually lasts for weeks to months but may last only hours or days. A clinical attack represents irreversible brain tissue injury. Following the attack, there is often partial recovery of function due to full or partial remyelination of the axons within the lesion known as remission, superimposed on relatively stable deficits resulting from residual damage to axons outside the lesion .

Subsequent attacks contribute progressively to more severe neurological disability that worsens over time (secondary progressive MS). About 10-15% of patients have more than one attack within the first two years followed by a secondary progressive disease course; approximately 20-25% of current cases are classified as secondary.

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